Premium
Cthrc1, a Novel Hormone Involved in Regulation of Metabolism
Author(s) -
Stohn J. Patrizia,
Perreault Nicole G.,
Wang Qiaozeng,
Liaw Lucy,
Lindner Volkhard
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.935.6
Subject(s) - endocrinology , medicine , anterior pituitary , glycogen , supraoptic nucleus , hormone , hypothalamus , chemistry , biology
We discovered Cthrc1 in a screen of balloon injured arteries. It is induced in adventitial cells of injured arteries and expressed in many developing and remodeling tissues. In this study we address the role of Cthrc1 in normal adult tissues. We generated mutant mice with a novel Cthrc1 null allele, which appeared developmentally normal. As they get older, livers from Cthrc1 null mice accumulate vast quantities of lipid, leading to extensive macrovesicular steatosis. In addition, glycogen levels and cell proliferation in skeletal muscle and liver of Cthrc1 null mice were significantly increased. However, Cthrc1 expression in the adult wild‐type mouse was found in the brain and osteocytes, but not in liver or muscle. Further investigation showed Cthrc1expression predominantly in the paraventricular and supraoptic nucleus of the hypothalamus. In pigs, Cthrc1 was detected around chromophobe cells of the anterior pituitary, in colloid‐filled follicles and the pituitary cleft. Development of a sensitive ELISA demonstrated that Cthrc1 circulates in human plasma in picogram/ml quantities. Cthrc1 is a novel circulating hormone produced by the anterior pituitary, hypothalamus and bone, and is involved in regulation of lipid storage and cellular glycogen levels. This study was supported by HL69182, P20 RR‐15555, P20RR018789/P20GM103465 and P30RR030927/P30GM103392.