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Influence of baclofen on upper airway and spinal motor drive during cough in the anesthetized cat
Author(s) -
Nicholas Justine Nicole,
Castillo Daniel,
Pitts Teresa E.,
Rose Melanie J.,
Bolser Donald C.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.930.17
Subject(s) - medicine , baclofen , anesthesia , parasternal line , airway , electromyography , cardiology , agonist , physical medicine and rehabilitation , receptor
The antitussive effects of (±) baclofen on upper airway muscle activities have not been determined. The hypothesis of this study was that administration of (±) baclofen would suppress upper airway muscle motor activity in a dose dependent manner during cough. Electromyograms (EMGs) of the parasternal, rectus abdominis, thyroarytenoid, posterior cricoarytenoid, and thyrohyoid muscles were measured along with esophageal pressure. Cough was elicited by mechanical stimulation of the lumen of the intrathoracic trachea. Baclofen (±) (3 – 10 μg kg −1 i.a.) induced decreases in EMG amplitude of the rectus abdominis during coughing and cough number per epoch. The durations of the inspiratory and expiratory (E1) phases of cough were prolonged by (±) baclofen. There was no effect of (±) baclofen on the EMG amplitudes of any of the laryngeal muscles, the parasternal, or the duration of the expiratory (E2) phase. Results from the present study indicate differential control mechanisms for laryngeal and spinal muscle motor drive during cough, providing evidence of a control system regulating upper airway activity that is divergent from that controlling drive to spinal motoneurons during cough. Supported by NIH HL89104, HL103415.