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Effect of repetitive coughing on swallowing in the anesthetized cat
Author(s) -
Spearman Daniel,
Pitts Teresa,
Rose Melanie J,
Mortensen Ashley,
Davenport Paul W,
Bolser Donald C
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.930.15
Subject(s) - swallowing , medicine , pharynx , anesthesia , airway , pharyngeal muscles , breathing , respiratory tract , larynx , respiratory system , anatomy , surgery
Aspiration can trigger repetitive coughing, and swallow can be inter‐laced between successive coughs to clear the pharynx of ejected material. We hypothesized that repetitive coughing would increase swallow drive and change swallow phase durations and amplitudes of pharyngeal or laryngeal muscle activities. Cough was induced by mechanical stimulation of the trachea and swallow was elicited by injection of water into the oropharynx in spontaneously breathing cats. Electromyograms (EMG) were recorded from pharyngeal, laryngeal and respiratory muscles. During coughing bouts, EMG amplitudes of the geniohyoid, cricopharyngeus, thyropharyngeus, thyrohyoid significantly increased compared to swallows during eupnea. Swallow‐related phase durations of specific muscles were unchanged during coughing. However, there was a significant reduction in the duration of laryngeal elevation and the total swallow time indicating reduced onset latencies between different upper airway muscle groups. These results support a theory of a highly cooperative airway protective network which responds to aspiration. This network must be present to ensure timely and efficient execution of swallow. Supported by NIH HL89104, HL103415, HL109025.