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Electrical stimulation of the aortic depressor nerve in conscious state elicits similar hemodynamic responses in heart failure and control rats
Author(s) -
TeixeiraPinto Tomás,
Toledo Durand Marina,
Lataro Renata Maria,
Castania Jaci Airton,
Silva Carlos Alberto Aguiar,
Fazan Rubens,
Salgado Helio Cesar
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.928.8
Subject(s) - baroreceptor , stimulation , baroreflex , medicine , hemodynamics , cardiology , heart failure , heart rate , femoral vein , anesthesia , femoral artery , blood pressure
Heart Failure (HF) is characterized by attenuation of the baroreflex. The present study investigated the hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) in HF rats. HF was induced by left coronary artery ligation. Six weeks after ligation (n=11), or sham surgery (control rats; n=12), the animals were anesthetized for femoral artery and vein cannulation and implantation of bipolar electrodes for ADN stimulation. Twenty‐four hours later, electrical stimulation of the ADN was applied during 20s (5, 15, 30, 60 and 90 Hz; 1mA; 2ms duration). Baseline mean arterial pressure (105 ± 3 vs 100 ± 4 mmHg in HF) and heart rate (341±10 vs 324±13 bpm in HF) were similar between HF and control rats. Electrical stimulation of the ADN (5 to 90 Hz) elicited similar hypotensive (14±2 to 49±6 vs 10±3 to 41±3 mmHg in HF rats) and bradycardic (17±6 to 75±15 vs 21±6 to 67±9 bpm in HF rats) responses in both groups. Taken into account that HF is characterized by baroreflex attenuation, these findings indicate a derangement of the baroreceptor endings and/or the electrical stimulation overriding the baroreflex attenuation in HF rats. Financial Support: FAPESP, CNPq.