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Neural signature of cerebral activity of the fetal cholinergic anti‐inflammatory pathway derived from heart rate variability
Author(s) -
Durosier Lucien Daniel,
Xu Alex,
Matushewski Brad,
Cao Mingju,
Herry Christophe,
Batkin Izmail,
Seely Andrew J.E.,
Ross Michael G,
Richardson Bryan S,
Frasch Martin G
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.926.11
Subject(s) - medicine , cardiology , fetus , endocrinology , pregnancy , biology , genetics
Fetal cholinergic anti‐inflammatory pathway (CAP) activity parallels changes in fetal heart rate variability (fHRV) in response to acidemia or inflammation. We hypothesized that 1) a multi‐domain fHRV measures approach will detect CAP activation early and 2) the degree of CAP activation will reflect the level of cerebral inflammation independent of the type of stimulus ‐ spontaneous hypoxia (n=5, arterial O2sat<50%), LPS (n=6) or control (n=9). Chronically‐instrumented near term fetal sheep underwent increasingly intense umbilical cord occlusions until fetal pH<7.00 (~3–4 h). FHRV measures Skewness, Assymetry Index (AsymI), RMSSD, Sample Entropy (SampEn) and Fuzzy Entropy (FuzEn) were calculated continuously using the automated and standardized Continuous Individualized Multiorgan Variability Analysis, and correlated to microglia (MG) counts in specific brain regions. RMSSD and FuzEn increased and SampEn decreased early. Measures of fHRV symmetry did not change with worsening acidemia but correlated to MG counts, with CA1 MG counts correlating only to AsymI. SampEn correlated most often to MG counts in all regions except the DG, which correlated to FuzEn, Skewness and RMSSD. The spatiotemporal pattern of correlation to fHRV measures of different property domains provides a neural signature of cerebral CAP activity. Funding: Women's Development Council, FRSQ, CIHR, MITACS/NeuroDevNet