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Clinical and Genetic Determinants of Blood Pressure Under Ambulatory Conditions on Days With and Without Acute Exercise
Author(s) -
Ash Garrett Igo,
Eicher John D.,
Tsongalis Gregory J.,
Thompson Paul D.,
Pescatello Linda S.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.910.15
Subject(s) - ambulatory , medicine , ambulatory blood pressure , blood pressure , diastole , cardiology , endocrinology
OBJECTIVE To identify clinical and genetic factors accounting for the variability in the BP response to acute bouts of dynamic exercise of varying intensity. METHODS 48 men (X±SEM 43.9±1.4yr, 29.5±0.7kg•m −2 ) with hypertension [systolic (SBP)/diastolic (DBP) 145.7±1.5/85.7±1.1mmHg] completed 3 randomly assigned experiments: a cycle exercise bout at LIGHT and VIGOROUS intensity and a CONTROL session of seated rest. Subjects left the laboratory wearing an ambulatory BP monitor. We obtained blood samples for the fasting cardiometabolic profile and genotyping. Multiple variable regression tested correlates of the daytime ambulatory BP response following exercise and CONTROL. RESULTS Clinical (30/18%) and genetic (0/6%) factors accounted for 30/24% of the variability in the SBP/DBP response following LIGHT (p=0.01); 27/52% [clinical (13/31%) & genetic (14/21%)] in the SBP/DBP response following VIGOROUS (p=0.01); and 18/29% [clinical (18/29%) & genetic (0/0%)] in the SBP/DBP response following CONTROL (p=0.02). CONCLUSION Our findings indicate that for every 10% increase in the intensity of a bout of acute dynamic exercise, the genetic contribution accounting for the variability in the SBP/DBP response increased by 1.2/2.0% (R 2 =0.779, p=0.08/R 2 =0.967, p=0.01), respectively. No such trends were found with clinical factors. Supported by American Heart Association Grant‐in‐Aid # 0150507N.