Premium
Age‐dependent hypertension and renal sodium handling in the female intrauterine growth restricted rat
Author(s) -
Paixao Ana Durce,
Ojeda N B,
Intapad S,
Fahling J,
Alexander B T
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.907.11
Subject(s) - offspring , endocrinology , medicine , renal function , sodium , kidney , blood pressure , biology , chemistry , pregnancy , genetics , organic chemistry
Hypertension in male offspring exposed to prenatal administration of glucocorticoids involves an increase in sodium transporter abundance. In a rodent model induced by placental insufficiency, female intrauterine growth‐restricted (IUGR) offspring are normotensive after puberty; however, there is an age‐dependent increase in blood pressure that occurs by one year of age, but the mechanism remains unknown. Thus, we hypothesized that an age‐dependent change in renal function and (Na + ‐K + ) ATPase activity may contribute to the development of hypertension in the female growth‐restricted rat. (Na + ‐K + ) ATPase activity in the basolateral membrane of the proximal tubule was similar in female growth‐restricted offspring relative to female control at one year of age (Control: 171±44 and IUGR: 76±18 nmol Pi/mg protein/min). Glomerular filtration rate also did not differ upon comparison of female growth‐restricted to female control (Control: 1.89±0.17 and IUGR: 1.57±0.17 ml/min/g kidney weight). In addition, hypertension at one year of age in female growth‐restricted offspring was not associated with changes in 24‐hour sodium or potassium excretion. Thus, these data indicate that alterations in renal sodium transport may not be an underlying mechanism of age‐induced hypertension in the female growth‐restricted rat. HL074927 ; HL51971; CAPES (Brazil)