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High‐intensity aerobic training restores the ability to modulate sympathetic vasoconstriction in contracting skeletal muscle of hypertensive and healthy middle‐aged individuals
Author(s) -
Mortensen Stefan P,
Nyberg Michael,
Gliemann Lasse,
Thaning Pia,
Hellsten Ylva
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.903.5
Subject(s) - vasodilation , medicine , tyramine , vasoconstriction , aerobic exercise , skeletal muscle , hemodynamics , endocrinology , cardiology , anesthesia
In young individuals, contracting skeletal muscle can override sympathetic vasoconstrictor activity (functional sympatholysis). To investigate the role of exercise training on functional sympatholysis in hypertension, we measured leg hemodynamics before and after an 8 week period of high intensity exercise training (3–4 times/week) in 8 untrained hypertensive (46±2 years) and 8 healthy controls (47±5 years) during leg exercise and arterial ATP infusion with and without infusion of tyramine. There was no difference in the vasodilatory response to infused ATP between groups. Tyramine induced a similar vasoconstrictor response in both groups and did not alter the vasodilatory response to ATP in either group. Before the training period, exercise hyperemia was lower in the hypertensive subjects (P<0.05) and tyramine lowered exercise hyperemia in both groups (P<0.05). After the training period, exercise hyperemia was similar in both groups and tyramine did not change exercise hyperemia in any of the groups. These results demonstrate that functional sympatholysis is impaired in the leg of both untrained healthy and hypertensive middle‐aged individuals and that exercise training normalizes functional sympatholysis. The vasodilatory and sympatholytic effect of plasma ATP does not appear to be affected by hypertension or the physical activity level. Supported by the Danish Research Council