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Comparing the degree of collateral vessel dilation necessary to compensate for a major arterial occlusion in mouse and man
Author(s) -
Arciero Julia,
DiStasi Matthew,
Unthank Joseph
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.902.9
Subject(s) - occlusion , medicine , arteriogenesis , collateral circulation , peripheral , cardiology , perfusion , hindlimb , collateral , blood flow , anatomy , ischemia , finance , economics
The dilation of pre‐existing collateral arteries is critical for providing adequate compensation following a major arterial occlusion, as seen in peripheral arterial disease (PAD). The lack of robust techniques for assessing perfusion in mouse has led to challenges in translating experimentally‐supported PAD therapies to the clinic. In this study, we develop a mathematical model to determine the impact of changes in collateral diameter and capillary number on blood flow at rest and during exercise after focal arterial occlusion in mice and humans. The model predicts the ratio of ligated to non‐ligated flow in the mouse hindlimb to be 0.54 if there is a combined 60% increase in collateral diameter and 71% increase in capillary number in the occluded limb. According to the model, the collateral diameter would have to increase in total by 133% to restore resting flow. The degree of enlargement for the mouse gracillis collateral artery is then compared with the enlargement necessary for the geniculate arteries in the human leg to restore resting flow.