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FORMULATION AND INVITRO EVALUATION OF OMEPRAZOLE LIPID MICROSPHERES
Author(s) -
Mohan S Dinesh,
Gupta V Rama mohan
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.893.12
Subject(s) - omeprazole , microsphere , coacervate , chemistry , particle size , chromatography , kinetics , pharmacology , drug , medicine , chemical engineering , physics , quantum mechanics , engineering
The current work formulation and invitro evaluation of Omeprazole lipid microspheres for the treatment of zolinger ‐ Ellison syndrome and H.pylori infection was carried out with objective of long‐term treatment for the syndrome. Lipid microspheres have great potential, time tested, safe, and stable at room temperature, easily mass produced yet cheaper. Omeprazole is a benzimidazole derivative, which decreases the gastric secretion, regardless of the primary stimulus with half‐life 1.4 hours in young and 2.9 hours with elderly patient. The treatment period from 6 months to 4 years depending on the condition. The lipid microspheres were prepared by coacervation and phase separation technique. The prepared formulation evaluated for various parameters like particle size, SEM, Drug release study, drug content uniformity, stability studies. The release study shows the formulation follows initially first order and later follows zero order kinetics. The stability studies limits with ICH guidelines. In the present work an attempt was made to study the release pattern of drug Omeprazole from various concentrations of lipid microspheres. The formulation coded D5 shows the maximum release retardant behavior, because of high proportion of lipid incorporation.