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Neuroprotective Activity of Berberis aristata against 6‐OHDA Induced Parkinson's Disease Model
Author(s) -
Magnnavar Chandrashekhar V,
Panji Avinash S,
Chinnam Sowmya
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.890.16
Subject(s) - neuroprotection , parkinson's disease , pharmacology , superoxide dismutase , antioxidant , catalase , berberis , oxidative stress , lipid peroxidation , medicine , chemistry , disease , traditional medicine , biochemistry
Objective Traditionally, the plant is used for various diseases, including neuronal disorders. To evaluate the neuroprotective activity of Berberis aristata DC.against 6‐OHDA Parkinson's disease in rat model. Materials and methods Parkinson's disease was induced by the striatal 6‐OHDA lesions. The behavioral assessments such as spontaneous locomotor activity, muscular coordination, and open field were studied along with antioxidant enzymatic and non‐enzymatic levels were estimated. Striatal infraction area, volume, estimation of Dopamine level was done by LC/MS/MS method. The histophathological studies were performed. Results The Berberis aristata DC. methanol extract showed anti‐Parkinson's disease activity by increase in behavioural activity and muscular coordination, decrease in clockwise rotation and in biochemical estimation there was significant decrease in lipid peroxidation (LPO) and increase in superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiols levels in extract treated groups as compared to control group. Striatal infraction area and volume was significantly reduced in extract treated groups as compared to control group. Conclusion The methanol extract of Berberis aristata DC.showed potent neuroprotective activity against 6‐OHDA induced Parkinson's disease in rat model.