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THE ANTAGONISM OF TRPV1 RECEPTORS PREVENT THE CARDIOVASCULAR CHANGES DURING SEPTIC SHOCK
Author(s) -
Alves Fernando Ferrari,
Reis Daniel Gustavo,
Resstel Leonardo,
Correa Fernando Morgan
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.876.5
Subject(s) - trpv , septic shock , medicine , sepsis , trpv1 , shock (circulatory) , antagonist , blood pressure , endocrinology , receptor , pharmacology , transient receptor potential channel
During sepsis there are changes in the cardiovascular system that is characterized by a drop in blood pressure (BP), an increase in heart rate (HR). It has been descript that during the septic shock the endocannabinoid system is active and in high concentrations they could act in vaniloids receptors (TRPV 1 ). Moreover the endocannabinoids, acting in TRPV 1 receptors are potent vasodilators, however, your participation has not been fully studied in the septic shock induced by cecal ligation and puncture (CLP). Methods Wistar rats had a radio‐telemetry probe introduced in a descendent aortic to measure cardiovascular activity. At the same time the sepsis was induced by CLP. The TRPV 1 antagonist SB366791 in a dose of 2ml/kg was injected intravenous immediately after the end of surgery and the cardiovascular parameters is measured by 8h. Institution's Animal Ethics Committee (N‐082/2010) Results The intravenous treatment with SB366791 a TRPV 1 antagonist did not alter the (BP) or (HR), PAM (97±4 vs 96±3 mmHg; t= 0.6, p>;0.05 n=5) and HR (343±4 vs 345±4 bpm; t=0.2; p>;0.05). The treatment with SB366791 was able to decrease the fall in (BP) (F (1,294) = 88, p<0.0001) and the increase in (HR) (F (1,294) =17, p<0,0001) during the septic shock caused by CLP. Conclusions The present results indicate that the TRPV 1 participate in the genesis of cardiovascular changes during septic shock caused by CLP.