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Three Rodent Strain‐wide comparisons: Cardio‐pathological markers in a mouse model subjected to repeated social aggressor
Author(s) -
Melige Monique Marie N
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.874.15
Subject(s) - atrophy , pathological , cardiomyopathy , social stress , histology , medicine , pathology , rodent , strain (injury) , biology , physiology , heart failure , psychiatry , ecology
Post‐traumatic stress disorder (PTSD), a common psychiatric disorder, is associated with the risk of cardiovascular (CV) atrophy and possible thromboembolic stroke. We examined the histology of cardiac samples from three mouse strains (C57BL/6j, BALB/cj and DBA/2j) that had been subjected to aggressor exposure (Agg‐E) for 5 or 10 d. Agg‐E mice were socially stressed; housed with aggressor mice (Agg) for 6 h/d without access to food/liquid and subjected to direct exposures with Agg at 3x/d at random times. Control mice (C) were put in the same environment without Agg. Cardiac tissues were harvested 1 d or 4 wks after 10‐day Agg‐E, and 1 d or 1.5 wks after 5‐day Agg‐E schedule, and were stained and examined using bright field microscopy. Cardiac tissues from C were harvested at the same time points. Agg‐E induced cardiomyopathy, specifically degeneration and inflammation, was mostly evident 1 d after 10‐day and 5‐day schedule among the Agg‐E mice of C57BL/6j. BALB/cj displayed a modest effect of stress; whereas DBA/2j displayed no sign of ailment. Mice of all three strains showed almost no trace of CV atrophy 4wks after 10‐day Agg‐E schedule; although after 1.5 wks post 5‐day schedules, traces of CV atrophy persisted only in C57BL/6j. In conclusion, C57BL/6j showed most effect of acute stress recovered with rest period. BALB/cj displayed a modest effect of stress and DBA/2j emerged as the most resilient strain.