Premium
Hyperactivity and Cognitive Flexibility in animals with Temporal Lobe Epilepsy
Author(s) -
Ramos Fabiane Ochai,
Cysneiros Roberta Monterazzo,
Scorza Fulvio Alexandre
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.873.8
Subject(s) - cognitive flexibility , epilepsy , cognition , status epilepticus , diazepam , pilocarpine , psychology , executive functions , medicine , temporal lobe , audiology , anesthesia , psychiatry
The temporal lobe epilepsy (TLE) can have a substantial impact on cognitive process. The rate of prevalence of Attention Deficit Hyperactivity Disorder (ADHD) in children with epilepsy is estimated from 12 to 39%, but the relationship between these two diseases is poorly understood and no validated animal models is available to exlplore this issue. This study investigated the cognitive flexibility and hyperactivity of animals with TLE. Male Wistar rats at 25 days post‐natal were submitted to epilepsy model by systemic administration of pilocarpine and controls received saline 0.9%. Diazepam (7,5 mg/kg. sc) was administered 3h after the onset of status epilepticus to stop or reduce behavioral seizures. Behavioral tests began at 60 days postnatal. The animals were divided into two groups: control and experimental. Operant conditioning box was used to evaluate executive functions: hyperactivity and cognitive flexibilility. Experimental group showed higher activity (total of lever press) [F[1,24] =48,26, p=0,0001] and reduced percentage of correct response [F[1,24] = 20.15, p=0,0020] than control group. In summary, the results suggest that epileptic animals exhibit hyperactive behavior, reduced performance on task and preservated cognitive flexibility. Supported by CNPq.