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Visfatin and vaspin protein concentrations in different tissues and insulin resistance
Author(s) -
Goktas Zeynep,
Wang Shu
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.865.13
Subject(s) - adipokine , adipose tissue , insulin resistance , medicine , endocrinology , insulin , obesity
Background In obesity, adipose tissue secretes many adipokines that have functions in insulin sensitivity. Visfatin and vaspin are known as insulin‐mimetic proteins and they might stimulate glucose uptake. Our research focuses on tissue visfatin and vaspin concentrations and their relationships to insulin resistance. Methods Thirty eight morbid obese (BMI ≥40) subjects had the subcutaneous, omental, and mesenteric adipose tissue, liver and muscle tissue samples taken at the time of Roux‐n‐Y surgeries. Visfatin and vaspin proteins were measured using ELISA kits. Fasting blood glucose and HbA1c levels and HOMA‐IR were measured before the surgery. Results were analyzed using ANOVA and Pearson correlation. Results Liver had significantly higher visfatin and vaspin concentrations than other tissues. There wasn't any significant difference in visfatin and vaspin concentrations among three different adipose tissues. Omental adipose tissue visfatin concentrations were positively correlated with HOMA‐IR and blood HbA1c levels (r = 0.456 and r = 0.481, respectively). Mesenteric adipose tissue vaspin concentrations were positively correlated with HOMA‐IR, blood glucose and HbA1c levels (r = 0.578, r = 0.467, and r = 0.455, respectively). Conclusions Our findings indicate that tissue visfatin and vaspin protein concentrations are involved in the development of insulin resistance during obesity. Grant Funding Source : TTU Research Fund