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Interlukin‐18, An Indicator of Insulin Resistance?
Author(s) -
Mabrouk Randa Reda,
Ghareeb Hala,
Elkabarity RANIA Hamdy
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.865.11
Subject(s) - insulin resistance , medicine , endocrinology , receiver operating characteristic , obesity , insulin , area under the curve , adipose tissue , homeostasis , gastroenterology
Adipose tissue expression of IL‐18 is increased in obesity but is not affected by weight loss, indicating that its plasma changes is related to insulin resistance rather than obesity. The study was designed to detect the level of IL‐18 and to determine its correlation with insulin resistance and inflammation in both morbidly obese and normal subjects. Quantitative analysis of hs‐CRP, IL‐18, Homeostasis Model Assessment ‐ Insulin Resistance Index (HOMA‐IR), and fasting insulin was performed in 35 morbidly obese individuals with fasting blood glucose>;100mg/dl and in matched healthy control group. IL‐18 was significantly higher in patients than in the control group. There was also a statistically significant correlation between IL‐18 and hs‐CRP (P<0.05) and a statistically significant correlation between IL‐18 and insulin and HOMA (P<0.05). Receiver‐operating characteristic (ROC) curve analysis was applied to assess the performance of IL‐18 as predictor of insulin resistance. The area under curve (AUC) was 0.890, and the optimum cut‐off level was 171pg/ml. This had a diagnostic sensitivity 100%, specificity 71.9%, negative predictive value (NPV) 100%, positive predictive value (PPV) 80.9%, and diagnostic efficacy of 87.1%. In conclusion, we have shown that high levels of IL‐18 are associated with an increased risk of insulin resistance, and that this is independent of obesity, hs‐CRP, triglycerides and cholesterol.