Premium
Bioelectrical impedance analysis (BIA) and phase angle: how relevant in cancer?
Author(s) -
Almeida Ana Isabel,
Ferreira Catarina,
Grillo Isabel Monteiro,
Camilo Maria,
Ravasco Paula
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.864.8
Subject(s) - bioelectrical impedance analysis , percentile , medicine , underweight , overweight , obesity , stage (stratigraphy) , cancer , body mass index , endocrinology , biology , paleontology , statistics , mathematics
We aim to characterise body composition (BC), concomitantly with phase angle (PA) & explore potential associations with histological aggressiveness & stage. We included 51 pts with solid tumours. BMI was calculated & categorised according to WHO's criteria; %body fat mass (%FM) & PA were assessed by BIA (Biodynamics 450®); %FM & PA were compared with age/sex reference values: percentage intervals & percentiles, respectively. Stages III/IV & moderately/poorly differentiated cancers were prevalent: 55% & 53%, respectively. By BMI, 61% pts were overweight/obese vs 2% underweight. Excessive FM was prevalent (67%) & also found in pts with normal BMI. PA<5 th percentile prevalence was of 16%. The prevalence of stage III/IV & moderate/low differentiated cancers was similar in normal BMI/FM as it was in obesity/high FM. Regarding PA, 86% & 83% pts with PA<5 th percentile had advanced & aggressive cancers, respectively vs pts with PA>;5 th percentile: 54% & 60% had advanced & aggressive cancers, respectively. Excessive FM by BIA was prevalent & underestimated by BMI. Advanced stage & aggressive cancers, indicators of worse disease status, were related with a lower PA. BC analysis & PA determination, both simple & quick for routine use, seem to bear a high clinical relevance. These preliminary results support the continuation of this study for additional analyses. No research support.