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Predictive Factors for Weight Loss Following Pancreatic Resection
Author(s) -
Hoffman Leah Allison,
Knehans Allen W.,
Postier Russell G.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.864.1
Subject(s) - weight loss , medicine , diabetes mellitus , pancreaticoduodenectomy , pancreatic cancer , surgery , pancreas , obesity , cancer , endocrinology
Pancreatic resection can compromise nutritional status and cause weight loss. Its primary indication is pancreatic cancer, where weight loss is associated with decreased quality of life and higher mortality. The goal of this study was to determine preoperative factors associated with postoperative weight loss so that at‐risk patients can be identified for nutrition intervention. A retrospective chart review of 74 patients who underwent pancreaticoduodenectomy or distal pancreatectomy was completed. Demographics and routine blood work were analyzed using a random coefficients model for linear regression to determine association with postoperative weight loss. Of the total 74 patients, 85% lost weight. Amount of weight loss was positively associated with time since surgery, preoperative weight, and preoperative serum albumin. Weight loss was not associated with hemoglobin, white blood cell count, total lymphocyte count, gender, age, malignancy, or diabetes. Postoperative weight loss was prevalent, and patients continued to lose weight after the typical convalescence period. In contrast to conventional nutritional assessment, patients who weighed more and had higher serum albumin lost more weight. Inflammation may play a role in this loss. Nutrition therapy should be a standard of care in for these patients to minimize postoperative weight loss. This project was supported by the Nutrition Department.