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Anti‐inflammatory Activities of Plant pigments
Author(s) -
Kim JongSang,
Kang Hye Ryung,
Kim Hyo Jung,
Seo Ji Yeon,
Park In Sil,
Kim Seong Soon,
Kim Bo Ram,
Zakharova Alexandra
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.862.11
Subject(s) - nitric oxide , nitric oxide synthase , pigment , lipopolysaccharide , inflammation , chemistry , christian ministry , macrophage , nf κb , pharmacology , biochemistry , signal transduction , biology , in vitro , immunology , philosophy , theology , organic chemistry
Natural colorants have become substantially popular as consumers are getting more interested in safety and wellbeing. As plant pigments have not been widely studied for their bioactive function, we attempted to evaluate the anti‐inflammatory activities of 24 kinds of plant‐derived colorants which were prepared by extraction with hot water. Among 24 kinds of samples, lac Dye, pagoda flower, deyer weed, dragons blood, and logwood showed relatively strong anti‐inflammatory effect. They effectively inhibited production of nitric oxide (NO) and inflammatory cytokines, and suppressed expression of inducible nitric oxide synthase (iNOS), cyclo‐oxygenase‐2 (COX‐2), and phosphorylation of nuclear factor (NF)‐kappa B p65 in lipopolysaccharide (LPS)‐treated murine macrophage Raw264.7 cells. In addition, we confirmed the suppression of TPA‐induced skin inflammation by the samples in a mouse model. These findings suggest that the five samples exert anti‐inflammatory action through the inhibition of NF‐kappa B signaling pathway. Grant Funding Source : Ministry of Knowledge Economy