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Effects of oriental plum extract on the cognitive function and the cerebral neurodegeneration‐related protein expressions in Type 2 diabetic rats
Author(s) -
Liao Hsiang,
Lee Kaoting,
Chien Yiwen,
Lin ShyhHsiang
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.861.6
Subject(s) - insulin resistance , neurodegeneration , morris water navigation task , type 2 diabetes mellitus , streptozotocin , medicine , endocrinology , type 2 diabetes , hippocampus , insulin , diabetes mellitus , disease
Recent studies indicate that Type 2 diabetes mellitus (T2DM) is one of the risk factors of Alzheimer's disease (AD). An impaired insulin signaling caused by insulin resistance may result in abnormal protein expressions in the brain and neuron damages. The study aimed to investigate the prevention of AD type neurodegeneration by consuming polyphenols‐rich oriental plum ( Prunus salicina Lindl) extract on T2DM rats. Nicotinamide/streptozotocin‐injection was performed to induce T2DM on male Wistar rats, followed by a 2 months oriental plum extract (OP) feeding intervention. The results showed that OP intervention significantly reduced insulin resistance by improving the Homeostasis model assessment‐insulin resistance (HOMA‐IR). Morris water maze results indicated the spatial learning function was improved after the OP consumption. The intervention also reduced amyloid‐β (Aβ) and phosphorylated tau (p‐tau) protein levels in the cerebral cortex and reduced Aβ deposition in the hippocampus of the T2DM rats. In conclusion, the oriental plum extract decreased the cognitive decline and reduced the expressions of AD‐type pathological proteins Aβ and p‐tau in T2DM rats. Grant Funding Source : Taipei Medical University