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Onion peel extracts have hepatoprotective effects and decrease blood levels of LDL cholesterol in liver injuried rats
Author(s) -
Chyun Jong Hee,
Park Hee Jin,
Yim JungEun
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.861.28
Subject(s) - tbars , carbon tetrachloride , chemistry , alkaline phosphatase , lipid peroxidation , antioxidant , quercetin , liver injury , cholesterol , alanine aminotransferase , lipid peroxide , medicine , biochemistry , endocrinology , pharmacology , enzyme , organic chemistry
Onion Peel Extracts (OPE) are known as rich sources of quercetin derivatives. Quercetin has been reported to have antioxidant and anti‐inflammatory properties. The objective of this study was to evaluate hepatoprotective effects of dietary OPE supplementation on liver injuries induced by carbon tetrachloride (CCl 4 ) in rats. OPE were extracted with ethanol, concentrated, and freeze dried to a powder. Thirty two Sprague‐Dawley rats were divided into control group, CCl 4 group, 0.15% OPE with CCl 4 group, and 3% OPE with CCl 4 group. Experimental diets were provided for four weeks. We measured blood lipid levels and enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Part of the liver was separated and lipid peroxide level(TBARS) was measured. CCl 4 cause a marked increase in the activities of serum ALT and ALP levels and the levels of TBARS in the liver. Supplementation of OPE significantly attenuated liver toxic effects of CCl 4 , and decreased the activities of ALT, and ALP. OPE offered a dose‐dependent hepatoprotective effects and the blood levels of LDL cholesterol were also decreased by supplementation of the OPE. These findings indicate that OPE have hepatoprotective effects in CCl 4 ‐indced liver injuries by reducing lipid peroxidation and enhancing antioxidant properties. Hepatoprotective effects of OPE improve blood cholesterol profiles.