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Consumption of bioactive ingredients modulates structure of lipoprotein particles
Author(s) -
Rivera Nancy,
German J Bruce,
Smilowitz Jennifer T.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.861.2
Subject(s) - postprandial , lipoprotein , cholesterol , food science , high density lipoprotein , chemistry , medicine , endocrinology , diabetes mellitus
Historically, food has defined everyday life, culture, and technology, and agriculture has responded by producing health‐targeted commodity‐based food products. Circulating high‐density lipoprotein cholesterol (HDL‐C) is inversely proportional to cardiovascular disease (CVD) risk. Recently, the structure of HDL particles has been shown to influence particle function. Bioactive ingredients available in the food supply influence HDL metabolism through multiple pathways. This study was designed to examine a novel approach in combining bioactive ingredients for their synergy to modulate HDL particle structure in the postprandial state. Twenty subjects provided blood before, 2 and 4 hours after consumption of three different dietary challenges on three separate days. The variation in plasma HDL and lipoprotein size distribution was explained by the combinations of bioactive ingredients, sex of the subjects and the postprandial period. This pilot study reveals a novel approach for targeting HDL particles using synergistic blends of bioactive components that target multiple metabolic pathways. Grant Funding Source : Unilever