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Pregnancy‐specific up‐regulation of zinc (Zn) absorption does not occur in indigenous Mayan population
Author(s) -
Hambidge K Michael,
Mazariegos Manolo,
Westcott Jamie E,
Miller Leland V,
Close Kelly,
Goco Norman,
Kemp Jennifer F,
Lei Sian,
Krebs Nancy F
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.860.4
Subject(s) - pregnancy , population , absorption (acoustics) , zinc , zoology , medicine , chemistry , obstetrics , biology , materials science , environmental health , genetics , organic chemistry , composite material
Absorption of Zn has been reported to be up‐regulated in late pregnancy (Donangelo, Nutrients, 2012) which has implications for estimating the effect of pregnancy on Zn dietary requirements. The objective of this study was to undertake a longitudinal study of Zn absorption pre‐pregnancy, first and third trimester in 17 indigenous Guatemalan women who were participating in a low phytate maize study with maize as the principal dietary component. Fractional absorption of Zn (FAZ) was determined using extrinsic labeling with a dual isotope tracer ratio method; duplicate diets were analyzed to determine total daily Zn intake (TDZ); total absorbed Zn (TAZ, mg/d) calculated from FAZ × TDZ. As there was only one difference between low‐phytate and control groups for one variable at one time, data were subsequently combined and significance across time points determined. Phase differences (mean (SD)) are summarized in the table: For both FAZ and TAZ there was a significant difference across the 3 time points, attributable to the Δ between preconception and early pregnancy phase for both FAZ and TAZ. A Spearman correlation for TAZ in the 1 st trimester phase showed that this was attributable to a lower TDZ. In conclusion, the results of this study did not support the concept of up‐regulation of Zn absorption specific to late pregnancy. Supported by Eunice Kennedy Shriver NICHD/NIH #HD04065.