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Organic mineral levels in the first 96‐hours post‐hatch impact performance and intestinal gene expression in broiler chicks
Author(s) -
Brennan Kristen M,
Graugnard Daniel E,
Samuel Ryan S,
Spangler Leya,
Ao Tuoying,
Pescatore Anthony J
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.859.10
Subject(s) - broiler , gene expression , gene , biology , lipid metabolism , metabolism , chemistry , andrology , medicine , biochemistry , zoology
A study was conducted to determine the effect of post‐hatch (0–96 h) organic mineral (Cu, Zn, Mn) levels on intestinal gene expression profiles in broilers. Chicks were randomly assigned to one of two treatment groups: corn‐soy diet with organic Zn, Cu, Mn (Bioplex ® , Alltech Inc.) at 100% (control, C) or 20% (low, L) of NRC requirements. After 96 h, 7 birds from each group were euthanized and jejunal gene expression was measured using Affymetrix Chicken Genome Array. Body weight, ADG and FCR did not differ between treatments at d 5. Overall 749 genes (432 up‐regulated; 317 down‐regulated) were differentially expressed in L vs C birds. Ingenuity pathway analysis indicated that the top biological functions with positive activation (z‐score >; 2) in L birds were related to molecular transport, nucleic acid metabolism, immune cell trafficking, lipid metabolism and cellular movement. Pathways associated with cell signaling (e.g., integrin‐linked kinase and Wnt/â‐catenin) and pathways related to cell growth and vascular homeostasis (sphingosine‐1‐phosphate and endothelin, respectively) were significantly activated by L compared with C. Gene expression profiles indicate that feeding broilers low concentrations of organic minerals in the first 96 h post‐hatch activates pathways and functions that aid in the development of the intestine.