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Resistin in Mexican adolescents: does altitude matter?
Author(s) -
ValdesRamos Roxana,
DominguezLopez María Alejandra,
TlatempaSotelo Patricia,
GuadarramaLopez Ana Laura,
Velasco Rosa Martha,
MartinezCarrillo Beatriz Elina,
OrosPantoja Rigoberto
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.855.9
Subject(s) - resistin , overweight , residence , medicine , altitude (triangle) , demography , obesity , analysis of variance , significant difference , effects of high altitude on humans , normal weight , pediatrics , insulin resistance , mathematics , adiponectin , geometry , sociology , anatomy
Resistin's role in the epidemic of chronic diseases is not yet clear and no normal values have been defined. As part of the initial evaluation of a physical activity and nutrition education intervention in Mexican overweight and obese adolescents, weight (kg), height (m), and plasma resistin concentrations (μg/mL) were determined in adolescents aged 12–14 from two cities located at different altitudes: Toluca (TO) (2679m) and Tuxtla Gutierrez (TG) (550m). Subjects were classified as normal (NL), overweight (OW) or obese (OB) according to CDC BMI for age and gender. The protocol was approved by the University's Ethics Committee; consent and assent were obtained from parents and adolescents previous to enrolment. Two‐hundred and forty adolescents were evaluated (30 NLTO, 30 NLTG, 56 OWTO, 69OWTG, 34 OBTO, 21 OBTG). No differences by BMI status were observed by one‐way ANOVA; while Student's t‐test showed a slightly significant gender difference (t= 2.196, p=0.29), and a highly significant difference by place of residence (t=13.707, p<0.001). Combination of nutritional status and residence by two‐way ANOVA resulted in highly significant differences (F=21.07, p<.001). The highest values found in TG Obese adolescents (low altitude) and the lowest values in the TO Obese subjects (high altitude). We conclude that altitude may be an important factor to take into account when analyzing resistin concentrations.