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Association of Apop gene polymorphism with obesity related phenotypes in Japanese population
Author(s) -
Okuno kumiko,
Tsuji Kumiko,
Yasuda Osamu,
Masaki Shiho,
Tanino Norikazu,
Katsuya Tomohiro,
Akasaka Hiroshi,
Rakugi Hiromi,
Fukuo Keisuke
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.855.18
Subject(s) - waist , snp , allele , polymorphism (computer science) , biology , obesity , phenotype , anthropometry , population , medicine , genetics , genotype , gene , endocrinology , single nucleotide polymorphism , environmental health
Background Previous gene polymorphism studies have suggested that proteins modulating mitochondrial function are implicated as diabetogenic candidates. Here, we show that the gene polymorphism of apoptogenic protein (Apop), a novel mitochondrial protein which nuclear‐encoded gene was up‐regulated in atherosclerotic lesions (J Biol Chem. 2006;281(33):23899–907), is associated with phenotypes related with obesity in Japanese population. Methods 1,517 Japanese subjects (60.8% women) were genotyped using TaqMan PCR method for the rs12889403 SNP in the Apop gene. We measured anthropometric indexes such as blood pressure, waist circumference and BMI in these subjects and the association between the rs12889403 SNP and these measurements was analyzed in the cross‐sectional analysis. Results We found that subjects with carriers of the T allele had significantly higher BMI (p=0.004), waist circumference (p=0.016) and diastolic blood pressure (p=0.020) compared with subjects with non‐T carriers. Additionally, subjects with the T allele younger than 65 years‐old had significantly higher serum insulin levels (p=0.040) as well as BMI (<0.001) and waist circumference (p=0.020) compared with subjects with non‐T carriers. Conclusions We suggest that a SNP (rs12889403) within the Apop gene is associated with obesity‐related phenotypes in Japanese subjects.