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Association between GFOD2 (rs12449157) polymorphism, dietary intake, anthropometric measurements and blood lipids in Mexican Subjects
Author(s) -
VazquezManjarrez Natalia,
GuevaraCruz Martha,
Tovar Armando R,
MedinaVera Isabel,
ErazoTapia Edmundo,
AguilarLopez Miriam,
FloresLopez Adriana,
Ordovas Jose M,
Torres Nimbe
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.855.13
Subject(s) - single nucleotide polymorphism , allele , medicine , endocrinology , snp , allele frequency , biology , polymorphism (computer science) , genotype , blood lipids , anthropometry , genetics , cholesterol , gene
It has been demonstrated the presence of single nucleotide polymorphisms (SNPs) in the recognition element seed sites of mRNA that are controlled by miRNA. One of this mRNA is the glucose fructose oxidoreductase domain containing 2 enzyme (GFOD2). Thus, the aim of this study was to assess the gene‐diet interaction between GFOD2 SNP, carbohydrate and total fat intake on blood lipids and anthropometric measurements. We studied 261 Mexican subjects, 60 men and 201 women. The frequency of the non‐common allele (G) was 21%. The frequency of homozygous for the non‐common allele (GG) and heterozygous (AG) was 38.8%. Homozygous subjects for the common allele (AA) decreased serum TG and increased BMI as the intake of dietary carbohydrates increased, whereas subjects with the non‐common allele showed the opposite pattern. In contrast, subjects homozygous for the common allele increased serum TG and decreased BMI as the total fat intake increased. Subjects with the non‐common allele showed the opposite pattern. These results indicate that the SNP for GFOD2 gene is a risk factor for the development of metabolic abnormalities associated with Metabolic Syndrome. Grant CONACYT 181685 (to MGC)