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Effect of lactation on antioxidant indices and bone mineral density in adult women
Author(s) -
Kamp Fernanda,
Gomes Vivianne Magalhães,
Silva Danúbia Incutto,
Bezerra Flávia Fioruci,
Torres Alexandre Guedes
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.850.9
Subject(s) - lactation , bone mineral , endocrinology , medicine , chemistry , calcium , antioxidant , zoology , osteoporosis , biology , biochemistry , pregnancy , genetics
The aims of this study were to compare indices of antioxidant status and bone mineral density (BMD) during lactation and to investigate the relationship of those indices with BMD. Lactating women (30.8 ± 4.8 y) with low calcium intake (≈600 mg/d), participated in the study at 2–4 (early lactation, EL; n= 14) and at 12–14 (middle lactation, ML; n= 11) wk postpartum. Indices of antioxidant status [ferric‐reducing ability of plasma (FRAP); erythrocyte aminolevulinic acid dehydratase activity (d‐ALAD); in vitro zinc‐d‐ALAD activation (Zn‐d‐ALAD%)] and measures of BMD [at total body (TBMD) and at lumbar spine (L2–L4)] were evaluated. When compared to EL, FRAP did not change, but Zn‐d‐ALAD% increased (P < 0.01), and d‐ALAD (P ≤ 0.05), TBMD (P ≤ 0.02) and L2–L4 (P ≤ 0.01) decreased, at ML. d‐ALAD was negatively associated with Zn‐d‐ALAD% (r= −0.63; p < 0.02), and tented to be positively associated with L2–L4 (r = 0.49; P = 0.07). No associations between FRAP and bone measurements were observed. Our results suggest that the decrease in d‐ALAD during lactation appears to be related to an impairment on zinc status, that could further contribute to accentuate bone loss during lactation, mainly in low calcium intake. Financial support: CNPq (Brazil)