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Maternal serum 25‐hydroxyvitamin D and fetal growth in a multicenter US study
Author(s) -
Gernand Alison D,
Simhan Hyagriv N,
Baca Katharyn M,
Bodnar Lisa M
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.848.19
Subject(s) - medicine , vitamin d and neurology , gestational age , birth weight , confounding , gestation , preeclampsia , obstetrics , small for gestational age , aspirin , logistic regression , pregnancy , fetus , genetics , biology
We examined the association between maternal serum 25‐ hydroxyvitamin D [25(OH)D] levels and measures of newborn size. Data came from a randomized controlled trial of aspirin for the prevention of preeclampsia in women at high risk for the disorder in 13 US medical centers. A total of 574 women delivered singleton, live births at term and had a serum sample drawn at ≤26 weeks gestation. Serum 25(OH)D was assayed with LC/MS‐MS. Multivariable linear and logistic regression models were used to assess the association between 25(OH)D and birth weight, length, head circumference, and risk of small‐for‐gestational‐age after adjustment for maternal prepregnancy BMI, race/ethnicity, age, gestational age at blood draw, and treatment allocation. Median birth weight was lower for women with 25(OH)D <30 nmol/L vs. ≥50 nmol/L (3200 g vs. 3395 g, p=0.004). After adjustment for confounders, 25(OH)D <30 nmol/L vs. ≥50 nmol/L was associated with a 168 g decrease in birth weight (95% CI: −301, −34). Furthermore, 25(OH)D 30–49 nmol/L vs. ≥50 nmol/L was associated with a 0.63 cm decrease in length (95% CI: −1.16, – 0.11). No association was observed for head circumference or risk of small‐for‐gestational‐age. Our results suggest that maternal vitamin D status may influence physiologic fetal growth in full term infants of high risk mothers. Supported by the National Institutes of Health grant HD056999 (PI: Dr. Bodnar).