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Dietary Patterns and prostate cancer risk: a population based cohort study in elderly Swedish men
Author(s) -
Ax Erika Helena,
Cederholm Tommy,
Grundmark Birgitta,
BillAxelson Anna,
Becker Wulf,
Holmberg Lars,
Zethelius Björn,
Garmo Hans,
Sjögren Per
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.847.8
Subject(s) - medicine , prostate cancer , cohort , hazard ratio , proportional hazards model , incidence (geometry) , cohort study , mediterranean diet , population , cancer , demography , gerontology , environmental health , confidence interval , physics , sociology , optics
The aim of this study was to assess the relationship between adherence to a modified Mediterranean Diet Score (mMDS) and a relatively low carbohydrate‐high protein score (LCHP‐score) and prostate cancer (PCa) incidence, in elderly Swedish men. In Uppsala Longitudinal Study of Adult Men, a Swedish population‐based cohort (n=1138, mean age 71±1), diet was determined by 7‐ d food records, and non‐adequate energy reporters were excluded. PCa cases were identified in the Swedish Cancer Register. Risk of PCa was analyzed with Cox proportional hazard regression. Exploratory analyses of nutrients identified by the World Cancer Research Fund as probable modifiers of PCa risk were conducted. During follow‐up (median 13.3y) 72 cases of PCa were identified. The mMDS was not associated with PCa. Adherence to the LCHP‐score was inversely related to PCa, with adjusted hazard ratios (HR) of 0.55 (0.32–0.96) for medium‐, and 0.47 (0.21–1.04) for high‐, compared with low adherence. Inclusion of selenium intake in risk models attenuated the association between the LCHP‐score and PCa, high vs. low adherence HR 0.70 (0.28–1.73). In this study, a moderately low carbohydrate‐high protein dietary pattern was associated with lower PCa incidence. A higher intake of selenium associated with the LCHP‐score was indicated to have contributed to observed relations.