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Association of maternal fruit and vegetable intake and blood cadmium concentration with neurobehavioral development of infant at 6 months: Mothers and Children′s Environmental Health (MOCEH)
Author(s) -
Kim Hyesook,
Jang Won,
Ha EunHee,
Park Hyesook,
Ha Mina,
Kim Yangho,
Hong YunChul,
Chang Namsoo
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.847.28
Subject(s) - pregnancy , medicine , offspring , bayley scales of infant development , cadmium , psychomotor learning , physiology , prospective cohort study , environmental health , gestation , cadmium exposure , biology , chemistry , psychiatry , toxicity , organic chemistry , genetics , cognition
Exposure to cadmium during pregnancy is known to increase oxidative stress, which may influence pregnancy outcomes and health of the child. This study investigated whether fruit and vegetable intake modifies the relationship between maternal blood cadmium concentration with neurobehavioral development of infant at 6 months. Blood cadmium concentrations in whole blood samples were analyzed from 860 pregnant women at mid pregnancy registered in the Mothers and Children's Environmental Health (MOCEH), a multi‐center prospective cohort study in South Korea, using graphite furnace atomic absorption spectrophotometry method. The dietary antioxidant intake during pregnancy was estimated using the 24‐h recall method, and infant mental development (MDI) and psychomotor development (PDI) were assessed by Bayley Scales‐¥ 2 at follow‐up. Multiple regression analysis after adjustment for covariates revealed that the blood cadmium level was negatively associated with the MDI (P=0.0092) and PDI (P=0.0033) of infant; these negative associations existed only when fruit and vegetable intake during pregnancy was below the median (537.2 g per day). These results suggest that an adequate maternal intake of fruit and vegetables is beneficial to the defense against the delays in neurobehavioral development associated with exposure to cadmium during pregnancy.