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Urinary Phytoestrogens and obesity outcomes in women: A cross‐sectional study of NHANES data, 1999–2004
Author(s) -
Farid Doaa Mamdouh,
Qureshi Mustafa,
Singer Martha,
Moore Lynn,
Hatch Elizabeth
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.847.2
Subject(s) - phytoestrogens , medicine , environmental health , national health and nutrition examination survey , obesity , cross sectional study , population , estrogen , pathology
Phytoestrogens are plant‐derived compounds that possess estrogenic activity and compete for the estrogen receptor. Dietary phytoestrogens are postulated to be inversely associated with obesity in women, but evidence conflicts, perhaps due to the small size of most previous studies. We analyzed the association between five phytoestrogens (daidzein, genistein, enterodiol, enterolactone and equol) and body mass index (BMI) and waist circumference (WC), using data for 1,581 women, ages 20 to 80 years, from NHANES, 1999–2004. Analysis of covariance modeling was applied to adjust for potential confounding by age, race, height, SES, creatinine, TV/video hrs, activity, smoking, parity, and diet patterns. Premenopausal women in the highest quartile of enterolactone (a lignan) had a BMI that was 1.9 kg/m2 lower than those in lowest quartile (p‐trend <0.011). Equol (an isoflavone metabolite) was statistically significantly associated with lower BMI and waist size in both pre‐ and post‐menopausal women (e.g., waist size in highest vs. lowest quartile of equol was 5 cm and 6.4 cm smaller for pre‐ and post‐menopausal women, respectively. Controlling for BMI, we found that equol in particular remained significantly inversely associated with waist size suggesting that benefits on central body may be independent of BMI. Hence, some phytoestrogens may have positive effects on body composition in women.Age and sex specific quartiles of Phytoestrogens and Body Composition parameters in females 20–55 years oldGrant Funding Source : None