Premium
The importance of hypercaloric diet components: alter metabolic parameters independent of time and the amount consumed and inflammatory only after prolonged intake
Author(s) -
Francisqueti Fabiane V.,
Nascimento André F.,
Luvizotto Renata A. M.,
Correa Camila R.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.846.5
Subject(s) - adiponectin , endocrinology , medicine , adipose tissue , leptin , calorie , triglyceride , insulin , adipokine , blood sugar , obesity , insulin resistance , diabetes mellitus , cholesterol
The aim was to evaluate the influence of short and long periods of high calorie diet on metabolic markers in plasma and inflammatory in adipose tissue. Male Wistar rats (10 weeks old) were divided to receive control diet (C, normal chow + water) or hypercaloric (DH, calorie diet + sugar water) for 6 or 24 weeks, constituting four groups: C6, C24, and DH6 DH24 (n = 8 animals/group). Were analyzed: final body weight (FW), adiposity index (AI), caloric and food intake (g), plasmatics metabolic parameters (blood glucose, triglyceride‐(TG), insulin, leptin, adiponectin, IL‐6 and TNF‐ α) and in adipose tissue (IL‐6 and TNF‐ α). Both experimental periods caused change in AI, blood glucose, TG, leptin, adiponectin and insulin in DH, even ingesting smaller amount of feed and no difference in caloric intake. However, only 24 weeks was associated with increased IL‐6 and TNF‐α only in adipose tissue. In conclusion, metabolic parameters were altered by the diet quickly, while inflammatory change in adipose tissue needed of a longer exposure to energy overload, showing that components of the diet are important, independent of the amount consumed. Financial Support: FAPESP (2011/14132–0)