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Maternal vitamin D status and inflammation across adolescent pregnancy
Author(s) -
Akoh Christine,
Pressman Eva,
Cooper Elizabeth,
Queenan Ruth Anne,
O'Brien Kimberly
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.846.4
Subject(s) - cord blood , medicine , pregnancy , vitamin d and neurology , gestation , inflammation , cohort , extant taxon , physiology , obstetrics , immunology , biology , genetics , evolutionary biology
Vitamin D is known to play a role in both innate and adaptive immunity, but the role of vitamin D in the inflammatory process during pregnancy is unclear. The purpose of this study was to examine associations between vitamin D status and inflammation across pregnancy using extant biospecimens obtained from a cohort of 168 pregnant adolescents (≤18 y). In this longitudinal study, serum was collected from adolescents at mid‐gestation (MG~26 weeks), delivery, and from cord blood; 66.1% of teens were African American, 33.9% Caucasian, and 24.1% Hispanic. Half of the teens and 60% of their newborns were 25(OH)D insufficient (≤20 ng/mL). Analyses are on‐going to measure inflammatory cytokines (IL‐6, IL‐10, TNF‐α, and CRP) in archived maternal and cord serum. To date maternal 25(OH)D at MG was positively correlated with TNF‐α in cord blood (p=0.0284, n=89). Maternal 1,25(OH)2D was positively associated with both TNF‐α (p=0.0364, n=96) and CRP at MG (p=0.0305, n=86) but was significantly negatively correlated with TNF‐α at delivery (p=0.0004, n=92). These results suggest that vitamin D may impact inflammatory activity in pregnant adolescents and their infants at birth. Grant Funding Source : USDA AFRI 2012–67017‐30216