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Dietary B‐vitamin and C‐reactive protein in people with Human Immunodeficiency Virus Infection
Author(s) -
Poudel Krishna C,
PoudelTandukar Kalpana
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.846.14
Subject(s) - nephelometry , medicine , c reactive protein , vitamin , vitamin b , human immunodeficiency virus (hiv) , group b , immunology , inflammation , gastroenterology , antibody
Background C‐reactive protein (CRP) has been associated with survival of HIV‐positive people. B ‐vitamin such as B‐6, B‐12 and folic acid are known to be inversely associated to CRP in people without HIV‐infection. We tested the hypothesis that higher intakes of B‐vitamin are associated with lower levels of CRP in a HIV‐positive people. Methods A cross‐sectional study was conducted among 250 HIV‐positive people aged 20–60 years residing in Nepal. Serum high‐sensitivity CRP concentrations were measured by the latex‐ agglutination‐nephelometry method. Dietary intake was assessed using two nonconsecutive 24‐hour dietary recalls. The relationship between B‐vitamin and CRP were assessed using multiple linear regression analysis. Results The mean intake of B‐vitamin were significantly higher in men than in women (P<0.001). Serum CRP concentration was inversely associated with B‐vitamin such as B‐1 (B=−1.5; P=0.003), B‐3 (B=−0.09; P=0.001), and B‐6 (B=−0.67; P=0.007) in men. CRP concentration was similarly associated with folic acid both in men (B=−0.002; P=0.09) and women (B=−0.003; P=0.06). Conclusion Higher intakes of B‐vitamin may have a beneficial role against inflammation in HIV‐positive people. Support: Grant‐in‐Aid for Young Scientists (B), Japan.