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The predictive ability of inflammatory biomarkers in patients with newly diagnosed Inflammatory Bowel Disease [IBD]: Analyses of preliminary pre‐ and post‐therapy data
Author(s) -
Zello Gordon,
Morris Marc W,
Fowler Sharyle,
Alcorn Jane,
Jayeoba Wemi,
Rezaie Elham,
Jones Jennifer
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.846.10
Subject(s) - medicine , calprotectin , inflammatory bowel disease , ulcerative colitis , gastroenterology , biomarker , faecal calprotectin , prospective cohort study , c reactive protein , crohn's disease , disease , cohort , inflammation , biochemistry , chemistry
Predictors of disease course in IBD would be beneficial for early determination of patient risk and appropriate medical therapy. To evaluate their predictive performance, endoscopic appearance, fecal calprotectin (Cp) and serological high sensitivity C‐reactive protein (hsCRP), markers of inflammation, were assessed in a prospective IBD (Crohn's disease [CD] and ulcerative colitis [UC]) inception cohort (<12 mo of diagnosis). Patients were observed at baseline and subsequent clinical visits (3 or 6 mo), where detailed endoscopic, clinical disease activity, and biomarker measurements were assessed. Of the 24 patients enrolled in the study, 14 were diagnosed with CD and 10 with UC. At enrolment, the median hsCRP was 4.1 mg/L (normal 0–7.0), and Cp was 644 μg/g (<50 normal). After therapy, the median Cp was 194 and 149 ug/g in CD (n=7) and UC (n=6), respectively. When stratified by clinical disease activity, no meaningful correlation between hsCRP and Cp was apparent, in contrast to a positive correlation with endoscopic appearance. Although the sample size is small, preliminary data suggest that the use of clinical disease activity measures in newly diagnosed IBD may be inadequate for determining inflammatory burden and for risk stratification. (Support from the Royal University Hospital Saskatoon and NSERC)