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Blood lead, iron deficiency and IQ in Uruguayan first‐graders
Author(s) -
Kordas Katarzyna,
Barg Gabriel,
Roy Aditi,
Manay Nelly,
Queirolo Elena I
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.845.30
Subject(s) - blood lead level , serum ferritin , pediatrics , medicine , iron deficiency , ferritin , intelligence quotient , lead poisoning , lead (geology) , lead exposure , cognition , anemia , psychiatry , biology , cats , paleontology
Cognition in children with both iron deficiency (ID) and elevated blood lead levels (BLL) is not well studied. In 1st‐grade children (n=150, age 6.4±0.6 y, 56.7% boys) from Montevideo, Uruguay we investigated associations among BLL ≥5μg/dL, serum ferritin (SF) <12μg/L), and IQ. Mean IQ, SF and BLL were 92.9±17.0 points, 15.0±14.1 μg/L, 4.7±2.2 μg/dL, respectively. Of the study children, 48.8 and 30.2% had BLL ≥5μg/dL and ID, respectively, 13.4% had both. BLL and SF were not correlated. In unadjusted linear regressions, BLL and SF were not independently associated with IQ; neither were BLL ≥5μg/dL nor ID. However, children with both elevated BLL and ID had lower IQ 11.7 points lower than their ID‐only peers (p=0.07). Preliminary analyses suggest that elevated BLL and ID may result in particularly poor cognitive function in school children. Sponsor: NIEHS 1R21 ES16523–01