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B vitamin intake in early adulthood and cognition in late midlife: CARDIA
Author(s) -
Qin Bo,
Xun Pengcheng,
Zhu Na,
Jacobs David,
Steffen Lyn,
Daviglus Martha,
Van Horn Linda,
Reis Jared,
Loria Catherine,
Liu Kiang,
He Ka
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.840.2
Subject(s) - niacin , digit symbol substitution test , verbal memory , medicine , b vitamins , vitamin , cognition , psychology , endocrinology , audiology , psychiatry , pathology , alternative medicine , placebo
Epidemiologic evidence regarding B vitamin intake in association with cognitive function in late midlife is limited. We hypothesized that higher intake of B vitamins predicted better cognition in late midlife. This study comprised a community‐based multicenter cohort of black and white men and women aged 18–30 years in 1985–1986 (Y0) from the Coronary Artery Risk Development in Young Adults (CARDIA) study. The CARDIA diet history at Y0 was used to assess nutrient intake, including dietary and supplemental B vitamins‐ thiamine, riboflavin, niacin and folic acid. Cognitive function was measured once at Y25 by Rey auditory‐verbal learning (RAVLT) for verbal memory, Digit symbol substitution test (DSST) for psychomotor speed, and modified Stroop interference test for executive function. After multivariate adjustment, the highest quintile (Q5) of riboflavin intake (median 5.4 mg/day) was significantly associated with 0.71 more words recalled in RAVLT (p=0.001 vs Q1, median 1.3 mg/day). 10 mg/day of niacin was associated with 0.3 more digits in DSST, the highest quintile of niacin intake predicted 3.6 more digits in DSST (p<0.001 vs Q1). We found a threshold association of folic acid intake with memory (0.6 word for Q5 vs Q1, p=0.001). In conclusion, higher intake of B vitamins in early adulthood was associated with better cognitive function in late midlife. Grant Funding Source : UNC Chapel Hill start‐up funding, Lineberger Cancer Center