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Vitamin K and cognitive function in healthy older adults. The NuAge Study
Author(s) -
Ferland Guylaine,
Presse Nancy,
Belleville Sylvie,
Gaudreau Pierrette,
Greenwood Carol E,
Kergoat MarieJeanne,
Morais Jose A,
Payette Helene,
Shatenstein Bryna
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.840.13
Subject(s) - episodic memory , cognition , verbal memory , effects of sleep deprivation on cognitive performance , california verbal learning test , executive functions , cognitive decline , psychology , verbal learning , vitamin , medicine , audiology , gerontology , dementia , disease , psychiatry
Evidence is accumulating from in vitro and rodent studies that vitamin K plays a role in brain and could have a positive effect on cognitive function, especially during aging. The present study examined cross‐sectional associations between vitamin K status and cognitive performance in 320 cognitively‐healthy men and women aged 70–85 y from the Québec Longitudinal Study on Nutrition and Successful Aging. Vitamin K status was measured as serum phylloquinone concentrations. Verbal and non‐verbal episodic memory, executive functions, and speed of processing were assessed using 13 cognitive scores from 6 tests. The median serum phylloquinone concentration was 1.06 nmol/L (range, 0.08–23.57 nmol/L). After adjustment for covariates including diet quality and serum lipid profile, higher serum phylloquinone concentration (log‐transformed) was associated with better cognitive scores ( Z ‐transformed) on the second (β = 0.47; 95% CI = 0.13 to 0.82), the third (β = 0.41; 95% CI = 0.06 to 0.75), and the 20‐min delayed (β = 0.47; 95% CI = 0.12 to 0.82) trials of the RL/RI‐16 Free and Cued Recall Task, a test of verbal episodic memory. No associations were found with non‐verbal episodic memory, executive functions, and speed of processing. Overall, our study provides evidence for a role of vitamin K in episodic verbal memory among healthy older adults. This research was supported by the Canadian Institutes of Health Research.