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Antibacterial activity and cytotoxicity of Aster sphathulifolius maxim. against oral‐bacteria and oral‐cancer cell lines
Author(s) -
Lee JeHyuk,
Kim GunHee
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.805.3
Subject(s) - cytotoxicity , microbiology and biotechnology , bacteria , viability assay , basal cell , traditional medicine , antibacterial activity , cell , chemistry , biology , medicine , biochemistry , in vitro , pathology , genetics
Whole plant‐extract of A. sphathulifolius showed the anti‐bacterial activities against tested oral pathogens except of S. aureus . The anti‐bacterial activities against S. mutans, S. sobrinus, S. pyogenes, and S. epidermidis were observed in most of all parts of A. sphathulifolius . However the growth of S. aureus was inhibited by only root‐extract of A. sphathulifolius. A. sphathulifolius showed the outstanding cytotoxicity against human oral gingival carcinoma cell with approximately 75.1 and 93.1% cell death in 250 and 500 μg/ml of concentrations, respectively. Cell viability of human oral squamous carcinoma cell and tongue carcinoma cell were suppressed to 13–18% at 1000 μg/ml of A. sphathulifolius. We showed that A. sphathulifolius extracts have the anti‐bacteria activity against oral pathogens and the cytotoxicity of oral carcinoma cell lines together. Taken together, it is anticipated that A. sphathulifolius might be used more actively for oral health care, as mouthwashes and toothpastes, even an alternative therapeutic drug.