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Remodeling and Regeneration in the Goldfish Heart
Author(s) -
Haag Maria T,
Grivas Jamie A,
Lafontant Pascal J
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.751.7
Subject(s) - danio , zebrafish , regeneration (biology) , ventricle , anatomy , biology , lumen (anatomy) , myocyte , cardiac ventricle , microbiology and biotechnology , pathology , medicine , genetics , gene
A remarkable ability for heart regeneration has been demonstrated in the zebrafish and giant danio, two members of the cyprinids family. While regenerative capacities appear widely distributed within genera, they can vary significantly in closely related species. Here we describe using light and electron microscopy the injury response and repair mechanisms in the heart of another cyprinid, the goldfish, following cautery injury to a small portion of the ventricular myocardium. We observed a robust inflammatory response in the first week consisting of infiltrating macrophages and heterophils. These inflammatory cells were identified in the lumen of spongy heart and in the compact layer of myocardium both adjacent and remote to the injury. Marked accumulation of collagen was observed during the second week in a border zone between healthy and injured myocardium, in adjacent sub‐epicardial regions, and was concurrent with a robust angiogenic response. The replacement of the ablated region of the ventricle was achieved by six weeks post‐cautery. PCNA‐positive cardiac myocytes (CM), as well as apparent de‐differentiated cardiac CM were present during repair. This data suggest that effective regeneration mechanisms operate in the injured goldfish heart, similar to that demonstrated in zebrafish and giant danio, and that cardiac regeneration may be widespread among cyprinids. Grant Funding Source : none