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Expression of Steroids Sex Hormone Receptors in the External Genitalia of She‐Camels ( Camelus dromedarius )
Author(s) -
Inpanbutr gnuch,
Emam Mahmoud A.,
ElZoghby Ihab,
Bakry Hatem,
Bolon Brod
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.750.5
Subject(s) - clitoris , biology , endocrinology , estrogen receptor , androgen receptor , seasonal breeder , medicine , vulva , sex hormone receptor , hormone , receptor , estrogen , anatomy , zoology , pathology , cancer , breast cancer , prostate cancer
To explore the role of hormonal fluctuations on external genitalia function in female camels, the localization and distribution of steroid sex hormone receptors were examined by immunohistochemistry in vestibule, vulva, and clitoris acquired during breeding and non‐breeding seasons. Animals (n=6 per season) were adults (5 – 10 years) with no history of reproductive tract or systemic disease. Estrogen receptor‐a (ERa) was expressed throughout all mucosal and submucosal tissues in all three regions. Progesterone receptor (PR) was expressed throughout the vestibule and along the mucosal surface of the vulva, but it could not be seen in vulvar skin and the clitoris. Androgen receptor (AR) was expressed throughout the vestibule, clitoris and vulvar mucosa. Epithelial expression of ERa and PR was higher during the breeding season, but AR was higher during the non‐breeding season. These data suggest that significant seasonal changes (p<0.05) in sex steroid receptor expression may play a role regulating external genitalia function in female camels. This paper was supported by grant from the government of Egypt (MAE and EME).