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Histological and immunohistochemical comparison of major salivary glands in young and old mice
Author(s) -
aka Naoko,
Nakamura Masanori
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.746.2
Subject(s) - saliva , immunohistochemistry , medicine , epithelium , submandibular gland , endocrinology , infiltration (hvac) , receptor , chemistry , biology , anatomy , pathology , materials science , composite material
Pituitary adenylate cyclase‐activating polypeptide (PACAP) is now recognized as the multi‐functional neuropeptide in various organs. We have examined the effect of PACAP for saliva secretion. In this study, we compared the parenchymal structure and the distribution of PACAP receptor, PAC1R, in three major salivary glands; parotid (PG), submandibular (SMG), sublingual (SLG) glands of young (8 weeks old) and old (8 months old) male C57BL/6 mouse. In PG, PAC1R was localized in the striated duct. In SMG, PAC1R was detected in the tall columnar epithelial cells in granular ducts and some of the cells in the striated ducts. In SLG, PAC1R was localized in the striated duct. No apparent difference of PAC1R was detected between young and old mice glands. In SLG of old mice, granular epithelial cells are detected in the striated duct. Furthermore, massive infiltrations of CD3‐ positive or B220‐positive lymphocytes were detected in old PG and SMG. These results suggested that PACAP regulated the saliva secretion by modulating the activity of striated duct and that lymphoid infiltration in PG and SMG but not in SLM might give the useful information for the etiology of autoimmune disease of salivary gland.