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Implication of nuclear progesterone receptor on respiratory control in newborn mice.
Author(s) -
Rossignol Orlane,
Potvin Catherine,
Uppari NagaPraveena,
Marcouiller François,
Bairam Aida,
Joseph Vincent
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.720.4
Subject(s) - hypoxic ventilatory response , respiratory system , apnea , medicine , peripheral chemoreceptors , endocrinology , plethysmograph , hypoxia (environmental) , control of respiration , ventilation (architecture) , receptor , biology , chemoreceptor , chemistry , oxygen , mechanical engineering , organic chemistry , engineering
We tested the hypothesis that nuclear progesterone receptors (PR) contribute to respiratory control development by studying newborn mice lacking PR expression (PRKO) or wild type controls (WT) at 1 and 4 postnatal days (P1 – P4). Minute ventilation was assessed under normoxia and in response to hypoxia (FiO2=14%, 12%, 10%, 20 min each) using whole body plethysmography. Hypoxic ventilatory response (HVR) was expressed as percentage changes from normoxia, apnea frequency was evaluated under normoxia. In P1 and P4 PRKO mice HVR was 2–3 times lower than in WT for the whole range of FiO2, during the early (peak response) and late (steady state) phase of HVR. In P1, the frequency of spontaneous apnea was lower in PRKO than in WT, while the frequency of post‐sigh apnea frequency was similar. In P4, the frequency of spontaneous and post‐sigh apnea was higher in PRKO than in WT. We conclude that the nuclear progesterone receptor plays a prominent role in respiratory regulation in newborn mice. Both phases of HVR (early and late) are disrupted in PRKO mice, likely indicating effects on peripheral chemoreceptors and central integration. Supported by CIHR.