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Physical Exercise Increases Bone Mineral Density of Osteopenic Diabetic Rats
Author(s) -
Sumida Doris Hissako,
Melo Yamamoto Aline Pedro,
Astolphi Rafael Dias,
Louzada Mario Jefferson Quirino
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.712.22
Subject(s) - bone mineral , medicine , endocrinology , tibia , osteoporosis , surgery
This study evaluated the changes caused by the absence of load in Bone Mineral Density (BMD) of diabetic rats (D) and the effectiveness of exercise on bone tissue. 64 male rats (5 days old) were divided into: control (C) and D (Streptozotocin i.p.). Sixty days later, the first BMD of the left tibia was measured by DEXA. Then, these groups were subdivided into 4 groups: C, Osteopenic control (OC), D and Osteopenic diabetic (OD). OC and OD were suspended by their tails for 21 days. Afterwards, other densitometric analyses (DA) were performed. Then, some of them were subjected to exercises (for 12 weeks) and the rats were subdivided again into 8 groups: 1) Exercised OC (EOC); 2) Sedentary OC (SOC); 3) Exercised Control (EC); 4) Sedentary Control (SC); 5) Exercised OD (EOD); 6) Sedentary OD (SOD); 7) Exercised Diabetic (ED); 8) Sedentary Diabetic (SD). After 12 weeks, the third DA was performed. In the first analysis (before suspension), there was a difference (p<0.05) in BMD between C and D. In the second evaluation (after suspension), an exacerbated reduction in BMD in OD compared to C, OC and D occurred (p<0.05). After exercising for 12 weeks, there was an increase in BMD in ED and EOD regarding SD and SOD (p<0.05). We concluded that there was a decrease in DMO in D compared to C group. Furthermore, the suspension period increased the loss of bone mass of OD and exercise improved BMD in diabetic rats. FAPESP 2010/14755–5.