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Higher volume of physical activity in the past year is associated with enhanced left ventricular diastolic function and exercise capacity and lower pressure wave reflection in healthy adolescents: no relation with time in sedentary activities
Author(s) -
Pierce Gary L,
Pajaniappan Mohanasundari,
DiPietro Amy,
Darracott Katherine V,
Guinter Mark,
Kapuku Gaston
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.712.15
Subject(s) - medicine , cardiology , diastole , blood pressure , diastolic function
We hypothesized that higher volume of physical activity (PA) in the past year would be associated with enhanced left ventricular (LV) diastolic function, exercise capacity and lower wave reflection in adolescents independent of time in sedentary activities (e.g., television viewing, etc.). Sixty healthy adolescents (age 16.4 ± 0.2 yrs) were studied. Subjects with higher (HPA, n=30, 25.7 ± 2.3 hrs/week) vs. lower (LPA, n=30, 6.9 ± 0.7 hrs/week) time spent performing PA in the past 12 months (Youth Adolescent Activity Questionnaire) demonstrated greater LV diastolic E/A (echo Pulsed doppler: 2.20 ± 0.07 vs. 1.90 ± 0.06, P<0.01), e′ (echo Tissue doppler: 0.19 ± 0.1 vs. 0.17 ± 0.1 m/s, P=0.03), VO2peak (40 ± 2 vs. 31 ± 2 ml/kg/min, p<0.01), exercise test duration (11.9 ± 0.5 vs.10.1 ± 0.4 min, P<0.01) and lower wave reflection (carotid aug index, −11.83 ± 2.6% vs. −4.77 ± 2.2%, P<0.05) compared with LPA. In the entire cohort, PA was associated with mitral E/A (r=0.31, P<0.02), e′ (r=0.30, P=0.05), carotid AI (r=−0.29, P<0.05), VO2peak (r=0.27, P<0.05) and exercise test duration (r=0.39, P<0.01). All relations except e′ remained significant after adjustment for time spent performing sedentary activities. Higher volume of PA in the past year is associated with enhanced LV diastolic function and exercise tolerance and lower wave reflection in healthy adolescents independent of time performing sedentary activities.