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Vitamin D receptor and Estrogen receptor alpha Genotype affects Exercise related Bone mass in Japanese healthy women
Author(s) -
Kondo Hiroyo,
Fujino Hidemi,
Murakami Shinichiro,
Fujita Naoto,
Nagatomo Fumiko,
Ishihara Akihiko
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.712.10
Subject(s) - calcitriol receptor , endocrinology , medicine , estrogen receptor alpha , bone remodeling , osteoporosis , peak bone mass , bone mineral , estrogen receptor , foki , bone density , vitamin d and neurology , genotype , polymorphism (computer science) , biology , genetics , cancer , breast cancer , gene
PURPOSE Osteoporosis is a systemic skeletal disease characterized by low bone mass and/or fragile bone. The vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) are a good genetic candidate for a prime regulator of bone metabolism. The purpose of this study was to assess the interactive effects of exercise, food intake, VDR and/or ESR1 polymorphism on bone mass. METHODS 240 healthy young women (20–23 yr) were recruited in this study. Bone mass and body composition were measured. Food frequency and exercise‐related questionnaires were used to estimate calcium intake and exercise intensity. The VDR (rs7975232) and ESR1 (rs2234693) polymorphisms were genotyped using the TaqMan‐based SNP method. RESULTS Exercise and milk‐intake were significantly associated with bone mass in the whole subjects. The bone mass in non‐exercised participants with CC homozygote in ESR1 was lower than that in TT homozygote. The bone mass in high‐intensity exercised participants carrying CC heterozygotes in ESR1 and VDR was significantly higher than that in low‐intensity. These results suggest that exercise attenuates are the increase of peak bone mass in young women carrying C allele in VDR and ESR1. Supported by Grants‐in‐Aid for Science Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology.