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Cardiopulmonary Fitness and Cognitive Function in Midlife: Associations with Central Elastic Arterial Stiffness and Regional Cerebral Perfusion
Author(s) -
Tarumi Takashi,
Gonzales Mitzi M,
Fallow Bennett,
Nualnim Nantinee,
Tanaka Hirofumi,
Haley Andreana P
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.709.6
Subject(s) - arterial stiffness , cardiology , medicine , cerebral blood flow , perfusion , cognitive decline , aerobic exercise , cognition , dementia , physical medicine and rehabilitation , blood pressure , psychiatry , disease
Central elastic arterial stiffness is associated with accelerated brain aging and cognitive decline. By contrast, habitual aerobic exercise reduces central arterial stiffness and is related to lower risk of dementia in late life. Purpose To determine the associations among cardiopulmonary fitness, central arterial stiffness, cognitive function, and regional cerebral perfusion in sedentary and endurance‐trained middle‐aged adults. Methods Maximal oxygen consumption (VO 2 max), neuropsychological assessment, central arterial stiffness, and regional cerebral perfusion were measured in 27 healthy sedentary (53±1 years) and 32 endurance‐trained (52±1 years) adults. Results The endurance‐trained subjects exhibited greater levels of VO 2 max, cognitive functions in total composite, memory, and attention‐executive function, and occipito‐parietal blood flow and lower central arterial stiffness than in sedentary subjects (all P<0.05). Carotid distensibility was significantly associated with both VO 2 max (r=0.28, P=0.046) and total cognitive composite score (r=0.30, P<0.05). Furthermore, central artery stiffness was negatively correlated with occipito‐parietal blood flow (r=−0.41–0.44, P<0.05). Conclusions Lower central arterial stiffness in endurance‐trained adults is associated with greater cognitive function and occipito‐parietal perfusion.