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Relapse of clinical symptoms in the acute experimental autoimmune encephalomyelitis (EAE) is adrenalectomy (ADX) time dependent in the Lewis rat
Author(s) -
QuintanarStephano Andrés,
ContrerasRomo Martha Citlalli,
IbarraPedroza Janeth Alejandra,
Zambrano Cynthia,
OrganistaEsparza Alejandro,
RodríguezPeralta Adriana,
GonzálezRuíz Claudia Rebeca,
Kovacs Kalman,
Berczi Istvan
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.690.6
Subject(s) - experimental autoimmune encephalomyelitis , medicine , multiple sclerosis , corticosterone , encephalomyelitis , immunology , adrenalectomy , immunization , glucocorticoid , immune system , hormone
Susceptible Lewis rats to acute experimental autoimmune encephalomyelitis (EAE) develop a single episode of paralysis, spontaneous recovery and remain refractory to EAE re‐immunizations. In non‐susceptible rats, EAE induces a strong corticosterone (CO) response protecting against the disease, whereas in the susceptible Lewis rats an inappropriate CO response induces an altered immune response. Here we study the critical time in which CO induce the refractivity to relapses in the EAE by using Lewis EAE‐adrenalectomized (ADX) animals operated at different times of EAE‐immunization. Animals were immunized with guinea pig brain homogenate in CFA (200 μL subcutaneously). Results All animals developed an acute episode of EAE symptoms which started at 10–11 days post immunization (DPI), however differences in the clinical course were apparent in the several groups. The Control group developed a single full‐blown disease without relapse. ADX 15 days before immunization and ADX 3 DPI groups developed a lethal form of EAE. ADX 20 DPI group developed a single full‐blown of EAE without relapse. ADX 27 DPI group developed the acute full‐blown symptoms with a full‐blown relapse. ADX 30 DPI group developed a mild but prolonged relapse. The ADX 36 DPI group developed a single full‐blown disease without relapse. Results indicate that there is a critical period (between 20–27 DPI), in which CO suppress the relapses of the EAE. Supported by UAA‐PIBB11–5 and CONACYT‐62317. México.