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Taurine supplementation initially accelerates salt‐induced nighttime hypertension in spontaneously hypertensive rats
Author(s) -
Suwanich Atchariya,
Roysommuti Sanya,
Wyss James Michael
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.689.5
Subject(s) - taurine , medicine , endocrinology , blood pressure , mean arterial pressure , zoology , chemistry , heart rate , biology , amino acid , biochemistry
This study examined the diurnal effects of taurine on salt‐induced hypertension in spontaneously hypertensive rats (SHR). Mature male Sprague‐Dawley rats were implanted with telemetry probes for continuous recording of mean arterial pressure. After a week on a basal (0.6%) NaCl diet, the rats were fed a 4% NaCl diet and drank water with or without 3% taurine for 3 weeks. While throughout the study, daytime mean arterial pressures were not significantly different between groups, nighttime arterial pressures were significantly higher in the taurine group within 9 nights of treatment (midnight control vs taurine; 136±4 vs 140±2 mm Hg before treatment; 138±6 vs 151±4 mm Hg at days 9 (p<0.05); 149±8 vs 148±4 mm Hg at days 20). The taurine rapidly increased arterial pressure within the first night and that arterial pressure reached its maximal increase by nights 2 of treatment. Interestingly, the nighttime differences between groups were consistently observed from 20.00h to 05.00h of the next days, coinciding with the active behavioral period of rats. However, during the first night, arterial pressure in the taurine group did not significantly elevate until 05.00h, while on subsequent nights, this differential rise began well before midnight. These data suggest that taurine supplementation initially accelerates salt‐induced hypertension in SHR during their active period, likely by increasing body sodium accumulation.